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Dolasetron mesylate CAS NO.: 115956-13-3 CAS NO.115956-13-3
- FOB Price: USD: 2.00-2.00 /Metric Ton Get Latest Price
- Min.Order: 1 Gram
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- Available Specifications:
top grade (1-10)Metric Tontop grade (1-10)Metric Tontop grade (1-10)Metric Ton
- Product Details
Keywords
- Dolasetron mesylate
- Dolasetron mesylate／(2alpha,6alpha,8alpha,9abeta)-Octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl-1H-indole-3-carboxylate monomethanesulfonate
- (2alpha,6alpha,8alpha,9abeta)-Octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl-1H-indole-3-carboxylate monomethanesulfonate
Quick Details
- ProName: Dolasetron mesylate CAS NO.: 115956-13...
- CasNo: 115956-13-3
- Appearance: Colorless liquid
- Application: Synthetic fragrances
- DeliveryTime: In stock
- PackAge: drum
- Port: China main port
- ProductionCapacity: 10000 Metric Ton/Month
- Purity: 99%
- Storage: Room temperature
- Transportation: By Sea/Air/DHL
- LimitNum: 1 Gram
- first class: 1-10
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Details
| Description | Dolasetron was launched as Anzemet in Australia and the US for the prevention of nausea and vomiting in chemotherapy patients. It is a highly potent and very selective antagonist of 5-HT3 receptors ; it is the sixth in this class of compounds to be marketed for the treatment of chemotherapy-induced emesis. The last two approved in this class were Nazasetron (1994) and Ramosetron (1996). Anzemet was prepared by a seven step sequence from a cyclopentenecarboxylic ester via a Robinson-Schopf cyclisation of a dialdehyde into a key 9-azabicyclo[3.3.l]nonan-3-one. In a clinical study with 164 cancer patients treated with Dolasetron mesylate prior to Cisplatin, single doses of 10- 50 mg achieved major control of nausea and emesis in 73% of subjects and were well tolerated. Results from pharmacokinetic studies in humans showed that the clinical effects and duration of action seem to be due mainly to a major plasma metabolite rapidly formed and very potent itself, the (+) enantiomeric alcohol obtained by enzymatic reduction of the cyclic ketone. |
| Originator | Hoechst Marion Roussel (Germany) |
| Uses | Nausea in chemotherapy;5-HT3 antagonist |
| Uses | Antidepressant |
| Uses | Dolasetron Mesylate acts as a bridged pseudopelletierine derivative; specific serotonin (5HT3) receptor antagonist. Antiemetic. |
| Brand name | Anzemet (Sanofi Aventis. |
| Veterinary Drugs and Treatments | Dolasetron may be effective in treating severe nausea and vomiting in dogs and cats, particularly if caused by cancer chemotherapy drugs. Because it is given once a day, the injectable form of dolasetron is often preferred over ondansetron, a similarly effective antiemetic. However, for oral use in small animals, dolasetron tablets are too large (50 and 100 mg) to be practically administered. |