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Tolperisone hydrochlorideCAS NO.3644-61-9 CAS NO.3644-61-9
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- Min.Order: 1 Kilogram
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- Product Details
Keywords
- Tolperisone hydrochloride
- 1-piperidino-2-methyl-3-(p-tolyl)-3-propanonehydrochloride
- 2,4'-dimethyl-3-piperidinopropiophenone monohydrochloride
Quick Details
- ProName: Tolperisone hydrochlorideCAS NO.3644-6...
- CasNo: 3644-61-9
- Molecular Formula: C16H24ClNO
- Appearance: colourless viscous liquid
- Application: Synthetic fragrances
- DeliveryTime: In stock
- PackAge: drum
- Port: China main port
- ProductionCapacity: 10000 Metric Ton/Month
- Purity: 99%
- Storage: Room temperature
- Transportation: By Sea/Air/DHL
- LimitNum: 1 Kilogram
- first class: 1-10
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Details
| Product Name: | Tolperisone hydrochloride |
| Synonyms: | 1-piperidino-2-methyl-3-(p-tolyl)-3-propanonehydrochloride;LABOTEST-BB LT00772344;2-Methyl-1-(4-methylphenyl)-3-(1-piperidyl)propan-1-one hydrochloride;Tolperizone hydrochloride;4'-METHYL-2-(1-PIPERIDINYLMETHYL)-PROPIOPHENONE HCL;4'-methyl-2-(1-piperidinylmethyl)-propiophenone hydrochloride;2,4'-DIMETHYL-3-PIPERIDINOPROPIOPHENONE HYDROCHLORIDE;2,4'-dimethyl-3-piperidinopropiophenone monohydrochloride |
| CAS: | 3644-61-9 |
| MF: | C16H24ClNO |
| MW: | 281.82 |
| EINECS: | 222-876-5 |
| Product Categories: | Intermediates & Fine Chemicals;Pharmaceuticals |
| Mol File: | 3644-61-9.mol |
| Tolperisone hydrochloride Chemical Properties |
| Melting point | 181-183°C |
| storage temp. | room temp |
| solubility | H2O: >20mg/mL |
| form | solid |
| color | white |
| PH | pH(50g/l, 25℃) : 4.5～5.5 |
| Water Solubility | almost transparency |
| Merck | 14,9522 |
| CAS DataBase Reference | 3644-61-9(CAS DataBase Reference) |
| Safety Information |
| Hazard Codes | Xn,Xi |
| Risk Statements | 20/21/22-52/53-36/37/38 |
| Safety Statements | 26-36-45-61-36/37-37/39 |
| WGK Germany | 3 |
| RTECS | UH1575500 |
| Toxicity | LD50 s.c. in mice: 620 mg/kg (Porszasz, 1961) |
| MSDS Information |
| Tolperisone hydrochloride Usage And Synthesis |
| Chemical Properties | White Solid |
| Originator | Tolperisone hydrochloride,Shanghai Abochem Chemical Co. |
| Uses | Tolperisone hydrochloride can be used as a muscle relaxant. |
| Manufacturing Process | To 1-(4-methylphenyl)-3-(1-piperidinyl)-1-propanol in chloroform was added an excess of thionyl chloride and the reaction mixture refluxed until completed. It was then taken to dryness under reduced pressure and the residue crystallized by dissolving in hot alcohol and diluting with ethyl acetate. An aqueous solution of the obtained N-[3-chloro-3-(p-tolyl)propyl]piperidine hydrochloride was hydrogenated at 3 atmospheres in the presence of buffered palladium-on-charcoal catalyst. 1-Piperidino-2-methyl-3-(p-tolyl)-3-propanone was purified by distilling the base (boiling point 106-107°C/1 mm) and reconverting to the hydrochloride, melting point 216-217°C. |
| Therapeutic Function | Muscle relaxant, Vasodilator |
| Biochem/physiol Actions | Tolperisone is derived from piperidine and possesses membrane stabilizing action. It helps in reducing the effect of spasticities associated with the nervous and muscular system. It exhibits muscle relaxant action through attenuating voltage-gated sodium channels in the brain stem. |