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Home > Products >  Methoxycarbonyl-L-tert-leucine CAS NO.162537-11-3

Methoxycarbonyl-L-tert-leucine CAS NO.162537-11-3 CAS NO.162537-11-3

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Keywords

  • Methoxycarbonyl-L-tert-leucine
  • MOC-L-tert.Leucine
  • (S)-2-Methoxycarbonylamino-3,3-dimethylbutyric acid

Quick Details

  • ProName: Methoxycarbonyl-L-tert-leucine CAS NO....
  • CasNo: 162537-11-3
  • Molecular Formula: C8H15NO4
  • Appearance: colourless viscous liquid
  • Application: Synthetic fragrances
  • DeliveryTime: In stock
  • PackAge: drum
  • Port: China main port
  • ProductionCapacity: 10000 Metric Ton/Month
  • Purity: 99%
  • Storage: Room temperature
  • Transportation: By Sea/Air/DHL
  • LimitNum: 1 Kilogram
  • first class: 1-10

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Details

Methoxycarbonyl-L-tert-leucine Basic information
Description References
Product Name: Methoxycarbonyl-L-tert-leucine
Synonyms: MOC-L-tert.Leucine;(S)-2-Methoxycarbonylamino-3,3-dimethylbutyric acid;Methoxycarbonyl-L-tert-leucine;N-(Methoxycarbonyl)-3-methyl-L-valine;N-Methoxycarbonyl-tert-leucine;Atazanavir related coMpound A;MOC-L-tert. Leucin;L-Valine,N-(Methoxycarbonyl)-3-Methyl-
CAS: 162537-11-3
MF: C8H15NO4
MW: 189.21
EINECS: 1308068-626-2
Product Categories: Amino Acid Derivatives;Amino Acids 13C, 2H, 15N;Amino Acids & Derivatives;Chiral Reagents
Mol File: 162537-11-3.mol
Methoxycarbonyl-L-tert-leucine Structure
 
Methoxycarbonyl-L-tert-leucine Chemical Properties
Melting point  1090C
Boiling point  320.9±25.0 °C(Predicted)
density  1.126±0.06 g/cm3(Predicted)
storage temp.  2-8°C
solubility  Soluble in ethyl acetate and methanol.
pka 4.46±0.10(Predicted)
form  powder
InChIKey NWPRXAIYBULIEI-RXMQYKEDSA-N
 
Safety Information
HS Code  2933399090
MSDS Information
 
Methoxycarbonyl-L-tert-leucine Usage And Synthesis
Description Methoxycarbonyl-L-tert-leucine is a kind of amino acid deriviative. It is a very useful intermediate for efficient synthesis of the HIV protease inhibitor BMS-232632 as well as atazanavir bisulfate. 
References Zhongmin Xu, †, et al. "Process Research and Development for an Efficient Synthesis of the HIV Protease Inhibitor BMS-232632." Organic Process Research & Development 6.3(2002):323-328.
Simhadri, Srinivas. "Process for the preparation of atazanavir bisulfate." (2016).
# q=14328-63-3
Chemical Properties White Solid
Uses The coupling of the two key intermediates, N-(methoxycarbonyl)-l-tert-leucine acylated benzyl hydrazine and chloromethyl ketone, via an S N 2 reaction furnished the amino ketone in high yield under our optimized conditions in practical synthesis of the HIV Protease Inhibitor Atazanavir via a Highly diastereoselective Reduction Approach.

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