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6-Biopterin CAS NO.22150-76-1 CAS NO.22150-76-1
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- Product Details
Keywords
- 6-Biopterin
- [S-(R*,S*)]-2-amino-6-(1,2-dihydroxypropyl)-1H-pteridin-4-one
- L-Biopterin,2-Amino-4-hydroxy-6-(1,2-dihydroxypropyl)pteridine
Quick Details
- ProName: 6-Biopterin CAS NO.22150-76-1
- CasNo: 22150-76-1
- Appearance: colourless viscous liquid
- Application: Synthetic fragrances
- DeliveryTime: In stock
- PackAge: drum
- Port: China main port
- ProductionCapacity: 10000 Metric Ton/Month
- Purity: 99%
- Storage: Room temperature
- Transportation: By Sea/Air/DHL
- LimitNum: 1 Kilogram
- first class: 1-10
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Details
| 6-Biopterin Basic information |
| Product Name: | 6-Biopterin |
| Synonyms: | [S-(R*,S*)]-2-amino-6-(1,2-dihydroxypropyl)-1H-pteridin-4-one;L-Biopterin,2-Amino-4-hydroxy-6-(1,2-dihydroxypropyl)pteridine;L-Biopterin(6-Biopterin);2-amino-6-(1,2-dihydroxypropyl)-1H-pteridin-4-one;(1R,2S)-Biopterin, 2-Amino-4-hydroxy-6-(1,2-dihydroxypropyl)pteridine, L-erythro-6-(1,2-Dihydroxypropyl)pterin;2-Amino-6-[(1S,2R)-1,2-dihydroxypropyl]pteridin-4(1H)-one;2-Amino-6-[(1S,2R)-1,2-dihydroxypropyl]pteridine-4(3H)-one;D-erythro-Biopterin |
| CAS: | 22150-76-1 |
| MF: | C9H11N5O3 |
| MW: | 237.22 |
| EINECS: | 244-807-8 |
| Product Categories: | Fluorescent Labels & Indicators;Bases & Related Reagents;Chiral Reagents;Heterocycles;Nucleotides |
| Mol File: | 22150-76-1.mol |
| 6-Biopterin Chemical Properties |
| Melting point | >210°C dec. |
| alpha | D24 -50° (c = 0.4 in 0.1N HCl); D24 -26° (c = 0.92 in 0.1N NaOH) |
| Boiling point | 379.74°C (rough estimate) |
| density | 1.3472 (rough estimate) |
| refractive index | 1.7610 (estimate) |
| storage temp. | 2-8°C |
| pka | 13.18±0.20(Predicted) |
| form | White to pale yellow powder. |
| Merck | 13,1229 |
| BRN | 87860 |
| CAS DataBase Reference | 22150-76-1(CAS DataBase Reference) |
| Safety Information |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| RTECS | UO3506000 |
| F | 10-23 |
| HS Code | 29339900 |
| Toxicity | sln-par-dmg 10 mg/L MUREAV 128,147,84 |
| MSDS Information |
| Provider | Language |
|---|---|
| SigmaAldrich | English |
| 6-Biopterin Usage And Synthesis |
| Description | L-Biopterin is the oxidized form of tetrahydro-L-biopterin (BH4), a nitric oxide synthase (NOS) cofactor. L-Biopterin can be reduced to BH4 via thioredoxin reductase followed by dihydropteridine reductase or reduced glutathione. It is extremely toxic to human melanocytes in culture (IC50 = 0.2 μM after 48 hrs). L-Biopterin is rarely found under physiological conditions except in the epidermis of patients with the depigmentation disorder Vitiligo. |
| Chemical Properties | Crystalline Solid |
| Uses | A pteridine widely distributed in nature; naturally occurring as the L-erythro-form. Considered as a growth factor for some insects. Fluoresces with a blue color in alkaline solution. |
| Uses | 6-Biopterin is an oxidation product from the melanogenesis regulating cofactor (6R)5,6,7,8 tetrahydrobiopterin (6-BH4). In vitro, 6-Biopterin is cytotoxic to melanocytes. However, in vivo, 6-Biopterin is rapidly and sequentially reduced back to 6-GH4 via |
| Uses |
6-Biopterin is an oxidation product from the melanogenesis regulating cofactor (6R)5,6,7,8 tetrahydrobiopterin (6-BH4). In vitro, 6-Biopterin is cytotoxic to melanocytes. However, in vivo, 6-Biopterin is rapidly and sequentially reduced back to 6-GH4 via q-BH2. Recent studies suggest that 6-Biopterin among other pteridines may be a useful non-invasive biomarker for cancer. |
| Definition | An enzymatic cofactor derived from pterin and involved in certain oxidation-reduction reactions. |
| Safety Profile | Moderately toxic by ingestion andintraperitoneal routes. Mutation data reported. Whenheated to decomposition it emits toxic vapors of NOx. |