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Sulbactam sodium CAS NO.:69388-84-7 CAS NO.69388-84-7
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Keywords
- Sulbactam sodium
- sodium (2s-cis)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4,4-dioxide
- sodium (2S,5R)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4,4-dioxide
Quick Details
- ProName: Sulbactam sodium CAS NO.:69388-84-7
- CasNo: 69388-84-7
- Molecular Formula: C8H12NNaO5S
- Appearance: white powder
- Application: Pharmaceutical intermediates
- DeliveryTime: In stock
- PackAge: bag
- Port: China main port
- ProductionCapacity: 10000 Metric Ton/Week
- Purity: 0.99
- Storage: Room temperature
- Transportation: By Sea/Air/DHL
- LimitNum: 1 Gram
- Heavy metal: N/A
- Grade: Industrial Grade,Pharma Grade
- first class: 1-6
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Details
| Sulbactam sodium Basic information |
| Product Name: | Sulbactam sodium |
| Synonyms: | SULBACTAM SODIUM;SULBACTAM SODIUM SALT;sodium (2s-cis)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4,4-dioxide;SODIUM SULBACTAM;4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid, 3,3-dimethyl-7-oxo-, 4,4-dioxide, sodium salt, (2S,5R)- (9CI);Antibiotic medicine CAS 69388-84-7 veterinary sulbactam sodium;(2S-cis)-3,3-Dimethyl-7-oxo-4-thia-1-azabicyclo[3,2,0]heptane-2-carboxylic acid 4,4-dioxide sodium salt;Sulbatam Sodium |
| CAS: | 69388-84-7 |
| MF: | C8H12NNaO5S |
| MW: | 257.24 |
| EINECS: | 273-984-4 |
| Product Categories: | pharmaceutical raw material;Antibiotic;Pharma;Chiral Reagents;Pharmaceutical raw materials;Inhibitors;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;API;APIs |
| Mol File: | 69388-84-7.mol |
| Sulbactam sodium Chemical Properties |
| Melting point | >230°C (dec.) |
| storage temp. | -20°C Freezer, Under Inert Atmosphere |
| solubility | Freely soluble in water, sparingly soluble in ethyl acetate, very slightly soluble in ethanol (96 per cent). It is freely soluble in dilute acids. |
| form | neat |
| InChIKey | NKZMPZCWBSWAOX-IBTYICNHSA-M |
| CAS DataBase Reference | 69388-84-7(CAS DataBase Reference) |
| Safety Information |
| Hazard Codes | Xn |
| Risk Statements | 42/43 |
| Safety Statements | 22-24-36/37-45-24/25 |
| HS Code | 29349990 |
| Toxicity | LD50 ivn-rat: 6500 mg/kg NKRZAZ 32(Suppl 4),97,84 |
| MSDS Information |
| Sulbactam sodium Usage And Synthesis |
| Description | Sulbactam sodium is a parenterally-active, β-lactamase inhibitor recently introduced as a 1: 1 combination product with cefoperazone. Like clavulanic acid, the first agent of this type to b e introduced, sulbactam enhances the effectiveness of β-lactam antibiotics against resistant strains. |
| Chemical Properties | White Solid |
| Originator | Pfizer (USA) |
| Uses | A semi-synthetic β-lactamase inhibitor. It is used in combination with β-lactam antibiotics as antibacterial. |
| Manufacturing Process | Sulbactam sodium is semi-synthetic antibiotic of penicillinic group. Start material for it's synthesis is 6-aminopenicillanic acid. First 6-aminopenicillanic acid was isolated in 1957 year from benzylpenicilline as resalt of treating of it by penicillinaze. Benzylpenicilline is produced by microorganism of genus Streptomyces. Further, 6-aminopenicillanic acid reacted with bromine, hydrochloric acid and NaNO2. As a result the 6,6-dibromopenicillanic acid was obtained. 6,6-Dibromopenicillanic acid was oxidized by KMnO4, to give 6,6-dibromo-1,1-The 6,6-dibromo-1,1-dioxopenicillanic acid in presence of Fe was converted to the 1,1-dioxopenicillanic acid (sulbactam acid). The sulbactam acid was treated by sodium 2-ethylhexanoate and crude sulbactam sodium was obtained. |
| Brand name | SULPERAZONE |
| Therapeutic Function | Beta-lactamase inhibitor |
| Safety Profile | Poison by intravenous route. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx and SOx |