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97-77-8 DisulfiramCAS NO.: 97-77-8 CAS NO.97-77-8
- FOB Price: USD: 4.00-5.00 /Gram Get Latest Price
- Min.Order: 1 Gram
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- Available Specifications:
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- Product Details
Keywords
- Disulfiram
- manufacturer Disulfiram
- high purity Disulfiram
Quick Details
- ProName: 97-77-8 DisulfiramCAS NO.: 97-77-8
- CasNo: 97-77-8
- Molecular Formula: C10H20N2S4
- Appearance: colourless liquid
- Application: Catalyst and Auxiliary
- DeliveryTime: In stock
- PackAge: Aluminium Foil Bag and Paper Drum
- Port: China main port
- ProductionCapacity: 10000 Gram/Day
- Purity: 99%
- Storage: Room temperature
- Transportation: By sea or by air
- LimitNum: 1 Gram
- first class: 1-10
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4.Customs Synthesis
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Details
| Chemical Properties | yellow-white crystals or grey powder |
| Uses | It is used as rubber accelerator; vulcanizer; seed disinfectant; fungicide; alcohol deterrent. |
| Uses | Alcohol deterrent;Dopamine beta-hydroxylase inhibitor |
| Uses | For the treatment and management of chronic alcoholism |
| Uses | Disulfiram is a copper and zinc chelator and an irreversible inhibitor of aldehyde dehydrogenase (IC50 = 0.1 mM) that has been indicated for the treatment of alcohol dependence. It also inhibits the copper-dependent enzyme dopamine β-hydroxylase, which prevents the breakdown of dopamine and has been considered as a treatment for cocaine dependence. When in complex with copper, disulfiram has been shown to inhibit purified 20S proteasome (IC50 = 7.5 μM) and 26S proteasome (IC50 = 20 μM) from MDA-MB-0231 breast cancer cells. Because disulfiram targets the ubiquitin-proteasome pathway, it has been investigated as an anti-cancer agent. Furthermore, at 250 nM it has been shown to induce reactive oxygen species, to activate JNK and p38 pathways, and to inhibit NF-κB activity, which suppresses self-renewal in cancer stem cells. |
| Definition | ChEBI: An organic disulfide that results from the formal oxidative dimerisation of N,N-diethyldithiocarbamic acid. A multi-enzyme inhibitor that is used in alcohol aversion therapy and also exhibits anticancer properties. |
| Brand name | Antabuse (Odyssey) . |