Cefoperazone sodium CAS NO.62893-20-3 CAS NO.62893-20-3

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Cefoperazone sodium
sodiumcefoperazone
(6R,7R)-7-[[(2R)-2-[[(4-Ethyl-2,3-dioxo-1-piperazinyl)carbonyl]aMino]-2-(4-hydroxyphenyl)acetyl]aMino]-3-[[(1-Methyl-1H-tetrazol-5-yl)thio]Methyl]-8-oxo-

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ProName: Cefoperazone sodium CAS NO.62893-20-3
CasNo: 62893-20-3
Molecular Formula: C25H28N9NaO8S2
Appearance: colourless viscous liquid
Application: Synthetic fragrances
DeliveryTime: In stock
PackAge: drum
Port: China main port
ProductionCapacity: 10000 Metric Ton/Month
Purity: 99%
Storage: Room temperature
Transportation: By Sea/Air/DHL
LimitNum: 1 Kilogram
first class: 1-10

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Product Name:	Cefoperazone sodium
Synonyms:	T-1551;sodiumcefoperazone;-tetrazol-5-yl)thio)methyl)-8-oxo-,monosodiumsalt,(6r-(6-alpha,7-beta(r*)));CEFAZONE;CEFOBID;CEFOBID SODIUM SALT;CEFOPERAZONE SODIUM;CEFOPERAZONE SODIUM SALT
CAS:	62893-20-3
MF:	C25H28N9NaO8S2
MW:	669.66
EINECS:	263-751-5
Product Categories:	Chiral Reagents;Heterocycles;Penicillins and Cephalosporins (beta-Lactams);A - KAntibiotics;Antibacterial;Sulfur & Selenium Compounds;Intermediates & Fine Chemicals;Pharmaceuticals;Antibiotics A to;Antibiotics A-FAntibiotics;Chemical Structure Class;Mechanism of Action;Spectrum of Activity;Pharmaceutical intermediate;Interferes with Cell Wall SynthesisAntibiotics;VIIBRYD;BPC;APIs
Mol File:	62893-20-3.mol

Cefoperazone sodium Chemical Properties

Melting point	200-202°C
storage temp.	Inert atmosphere,2-8°C
solubility	H₂O: 50 mg/mL, clear, faintly yellow
form	powder
Water Solubility	Soluble in water. Slightly soluble in alcohol.
Merck	13,1943
BRN	4902135
InChIKey	NCFTXMQPRQZFMZ-WERGMSTESA-M
CAS DataBase Reference	62893-20-3(CAS DataBase Reference)

Safety Information

Hazard Codes	Xn
Risk Statements	42/43
Safety Statements	22-36/37
WGK Germany	2
RTECS	XI0374000
HS Code	29419000

MSDS Information

Cefoperazone sodium Usage And Synthesis

Chemical Properties	Faint beige powder
Originator	Cefobid,Pfizer,W. Germany,1981
Uses	For studying the expression, binding, and inhibition of penicillin-binding proteins.Cefoperazone sodium salt is used in the study of drug-protein binding, expression and inhibition of penicillin-binding proteins during cell wall synthesis. It is as an antibacterial and antimicrobial agent useful for prevention of postoperative infection. It is used as an inhibitor of inactivation of alfa-antitrypsin.
Uses	Broad spectrum third generation cephalosporin antibiotic. An antibacterial.
Uses	antidepressant, serotonin reuptake inhibitor, 5HT1A agonist
Manufacturing Process	To a suspension of 3.0 g of 7-[D-(-)-α-amino-p-hydroxyphenylacetamido]-3- [5-(1-methyl-1,2,3,4-tetrazolyl)thiomethyl]- 3-cephem-4-carboxylic acid in 29 ml of water was added 0.95 g of anhydrous potassium carbonate. After the solution was formed, 15 ml of ethyl acetate was added to the solution, and 1.35 g of 4-ethyl-2,3-dioxo-1-piperazinocarbonyl chloride was added to the resulting solution at 0°C to 5°C over a period of 15 minutes, and then the mixture was reacted at 0°C to 5°C for 30 minutes. After the reaction, an aqueous layer was separated off, 40 ml of ethyl acetate and 10 ml of acetone were added to the aqueous layer, and then the resulting solution was adjusted to a pH of 2.0 by addition of dilute hydrochloric acid. Thereafter, an organic layer was separated off, the organic layer was washed two times with 10 ml of water, dried over anhydrous magnesium sulfate, and the solvent was removed by distillation under reduced pressure. The residue was dissolved in 10 ml of acetone, and 60 ml of 2-propanol was added to the solution to deposit crystals. The deposited crystals were collected by filtration, washed with 2- propanol, and then dried to obtain 3.27 g of 7-[D-(-)-α-(4-ethyl-2,3-dioxo)-1- piperazinocarbonylamino)-p-hydroxyphenylacetamido]-3-[5-(1-methyl- 1,2,3,4-tetrazolyl)thiomethyl]- 3-cephem-4-carboxylicacid, yield 80.7%. The product forms crystals, MP 188°C to 190°C (with decomposition).
Brand name	Cefobid (Pfizer).
Therapeutic Function	Antibiotic
Clinical Use	Cefoperazone sodium is a third-generation, antipseudomonalcephalosporin that resembles piperacillinchemically and microbiologically. It is active against manystrains of P. aeruginosa, indole-positive Proteus spp.,Enterobacter spp., and S. marcescens that are resistant tocefamandole. It is less active than cephalothin againstGram-positive bacteria and less active than cefamandoleagainst most of the Enterobacteriaceae. Like piperacillin,cefoperazone is hydrolyzed by many of the β-lactamasesthat hydrolyze penicillins. Unlike piperacillin, however, itis resistant to some (but not all) of the β-lactamases thathydrolyze cephalosporins.Cefoperazone is excreted primarily in the bile. Hepaticdysfunction can affect its clearance from the body.
Veterinary Drugs and Treatments	Cefoperazone is used to treat serious infections, particularly susceptible Enterobacteriaceae not susceptible to other less expensive agents or when aminoglycosides are not indicated (due to their potential toxicity).

Cefoperazone sodium CAS NO.62893-20-3 CAS NO.62893-20-3

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