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Barnidipine CAS NO.: 104757-53-1 CAS NO.104757-53-1
- FOB Price: USD: 2.00-2.00 /Metric Ton Get Latest Price
- Min.Order: 1 Gram
- Payment Terms: L/C,D/A,D/P,T/T,MoneyGram,Other
- Available Specifications:
top grade (1-10)Metric Tontop grade (1-10)Metric Tontop grade (1-10)Metric Ton
- Product Details
Keywords
- Barnidipine
- Barnidipine Hydrochloride
- hydrochloride,(s-(r*,r*))-hyl1-(phenylmethyl)-3-pyrrolidinyleste
Quick Details
- ProName: Barnidipine CAS NO.: 104757-53-1
- CasNo: 104757-53-1
- Appearance: Colorless liquid
- Application: Synthetic fragrances
- DeliveryTime: In stock
- PackAge: drum
- Port: China main port
- ProductionCapacity: 10000 Metric Ton/Month
- Purity: 99%
- Storage: Room temperature
- Transportation: By Sea/Air/DHL
- LimitNum: 1 Gram
- first class: 1-10
Superiority
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2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...)
3.OLED intermediates (Fluorene,Carbazole,Boric acid...)
4.Customs Synthesis
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Details
| Safety Information |
| Toxicity | LD50 orally in male, female rats: 105, 113 mg/kg (Satoh) |
| MSDS Information |
| Barnidipine Usage And Synthesis |
| Description | Barnidipine hydrochloride is a vasodilating dihydropyridine calcium antagonist useful in the treatment of hypertension. In experimental animals, its hypotensive effect was more potent and longer acting than nicardipine, nifedipine and nitrendipine. |
| Description | Barnidipine is a dihydropyridine calcium channel blocker that has an IC50 value of 0.35 nM in potassium-induced tonic contraction of pig coronary artery. It demonstrates antihypertensive activity by reducing peripheral vascular resistance. It decreases blood pressure in spontaneously hypertensive rats when administered orally at 1 and 3 mg/kg per day. Formulations containing barnidipine have been used as a treatment for hypertension. |
| Chemical Properties | Pale Yellow Solid |
| Originator | Yamanouchi (Japan) |
| Uses | 1,4-Dihydropyridine calcium antagonist with antihypertensive and diuretic effects. A potential candidate in the treatment of patients with renal parenchymal hypertension. |
| Manufacturing Process | In 5 ml of isopropyl alcohol were dissolved 1.5 g (0.01 mole) of 3- nitrobenzaldehyde, 2.6 g (0.01 mole) of 1-benzyl-3-acetoacetyloxypyrrolidine, and 1.3 g (0.01 mole) of β-aminocrotonic acid methyl ester and then the solution was refluxed for 8 hours. The solvent was distilled off under reduced pressure, the residue obtained was dissolved in a small amount of chloroform, and the solution was applied to silica gel column chromatography (column diameter 1.5 cm, height 20 cm, and about 200 ml of chloroform was used as the eluent). The eluates were collected and concentrated to give 3.4 g of oily 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid-3- (1-benzylpyrrolidin-3-yl)ester-5-methyl ester: [α]D 20=+64.8° (c = 1 in methanol). |
| Brand name | Hypoca |
| Therapeutic Function | Coronary vasodilator |